Win32::GUI is faster than wxPerl in my case perhaps because the data file used in my case contains both English and Chinese characters and the Chinese characters get displayed much faster on screen when using the native API of a Chinese system.
Is your wxPerl built with unicode support?
In my latest results, wxPerl is the fastest by a one to two seconds
$ perl zj907592tk.pl
Total running time: 00:00:07
at zj907592tk.pl line 64, <$data> line 7553.
$ perl zj907592w32.pl
Total running time: 00:00:08
at zj907592w32.pl line 64, <$data> line 7553.
$ perl zj907592wx.pl
Total running time: 00:00:06
at zj907592wx.pl line 70, <$data> line 7553.
Total running time: 00:00:06
at zj907592wx.pl line 70, <$data> line 7553.
The chinese I got from
http://corpus.leeds.ac.uk/internet.html looks like gibberish on my us english laptop