The plethora of technologies in your post illustrates the core problems:

- Native GUI is platform dependent

- Cross-platform GUI is hard to do "right".

- "Right"ness is an extremely subjective and contentious subject, leading to a lot of mutually-incompatbile solutions.

There is no one "right" answer. You have to evaluate the alternatives and pick what's the best fit for your particular set of circumstances. It would be nice if the Perl community could reach consensus on the issue, but that hasn't happened and is unlikely to.