I find most of my co-workers, who recently started using Perl, get rather frustrated with all the funny symbols. Also, the OOP is kinda weak. Moose fixes that, but costs a lot to load up and came a little late in the game.

I don't find these things so bad personally, but some people do. The real question is: why come to a site full of Perl fans to see what's so bad about Perl? We like it. Try the Python forums. They'll have a list of complaints.