#!/usr/bin/perl -w

use Tk;

sub grab;
sub st;

my $me = MainWindow->new;
$menubar = $me -> Frame() -> pack('-side' => 'top','-fill' => 'x');
$filemenu = $menubar -> Menubutton('-text' =>'file') -> pack('-side' =
+>
'left');

$filemenu -> command(
-label   => 'help',
-command => sub{st;}
);
$filemenu->separator();
$filemenu->command('-label'=>'exit','-command'=>sub {exit});

$me->Button(-text => 'translate to 1337',
    -command => sub{grab;}
)->pack;

$text1 = $me->Text (-font=>'14','-width'=>40, '-height'=> 1
)->pack;

$me->Label(-text=> '1337 5p34k'
)->pack;

$text2 = $me->Text (-font=>'14','-width'=>40, '-height'=> 1
)->pack;

MainLoop;


sub grab
{
my $take = $text1->get('1.0','end');

        $take =~ s/you/joo/ig;
        $take =~ s/\b(own)/pwn/ig;
        $take =~ s/good/leet/ig;
        $take =~ s/great/leet/ig;
        $take =~ s/cool/dope/ig;
        $take =~ s/kill/frag/ig;
        $take =~ s/hack/hax/ig;
        $take =~ s/ing/xoring/ig;
        $take =~ s/stupid/nub/ig;
        $take =~ s/dumb/nub/ig;
        $take =~ s/soo+/uber/ig;
        $take =~ s/very/uber/ig;
        $take =~ s/beginner/nub/ig;
        $take =~ s/fear/phear/ig;

        $take =~ tr/aA/4/;
        $take =~ tr/oO/0/;
        $take =~ tr/Ee/3/;
        $take =~ tr/lL/1/;
        $take =~ tr/tT/7/;
        $take =~ tr/sS/5/;
        $take =~ tr/zZ/2/;

$text2->delete('1.0','end');
$text2->insert('1.0',"$take");
}

sub st
{
my $me2=MainWindow->new;
$me2->Label(-text=>'Created By: Narmak',
-font=>'20')->pack;
$me2->Label(-text=>'1337 5p34k Visual Version 1.0',
-font=>'20')->pack;
}
[download]

Ok, first please use strict and warnings in your scripts. For informations, type:

perldoc strict 
perldoc warnings
[download]

on your shell/prompt.
Then, if you have problems with -gui option, first of all do NOT use -gui option and run the executable from the command line (not double click on it).
Doing this, the exe tells you the problems.

In your case, you're missing some "use somemodule" needed by perl2exe (see the manual shipped with perl2exe).

So add

use Tk::Menubutton;
use Tk::Text;
[download]

in your script and all goes well.