Here's a simple example script.

#!/usr/bin/perl -w
use strict;

# make html/forms easy to deal with
use CGI;

# report errors in the browser
# (remove from production code)
use CGI::Carp 'fatalsToBrowser';

# create new CGI object
my $q = new CGI;

if ( ! $q->param() )
{
    # first run, so present form
    print
        $q->header,
        $q->start_html,
        $q->start_multipart_form,
        $q->filefield('file'),
        $q->br,
        $q->submit('Upload'),
        $q->end_form,
        $q->end_html;
}
else
{
    # file uploaded, so process it

    # read filehandle from param and set to binary mode
    my $filehandle = $q->param('file');
    binmode $filehandle;

    # open file for output. Change this to suit your needs!!!
    open OUT, "> /path/to/local/filename" or die $!;
    binmode OUT;

    # process $filehandle
    {
        my $buffer;
        while ( read $filehandle, $buffer, 1024 )
        { 
            print OUT $buffer;
        }
    }

    close OUT;

    # show success
    print
        $q->header,
        $q->start_html,
        $q->p('File uploaded'),
        $q->end_html;
}
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