#!/usr/bin/perl -w

use strict;
use CGI qw/ :standard *table /;
use CGI::Pretty; # not necessary, but it makes for more legible html output


my $db ="test.txt";

# moved header and start_html outside of loop
# print takes a list, so you can join several items to print with commas

print
    header,
    start_html( -title => 'Script' ),
    hr,
    start_table( { -width => '100%', -border => '0' } );


# It's more helpful to include $! in the error

open( FILE, "<$db" ) or die "Well, whats up.. can't open file $!\n";


while ( <FILE> ) {

    # no need to define $line here -- $_ is already defined, so you can use it 
    # directly

    chomp;

    # Just a preference note.  When working with arrays, I prefer to use
    # something a little easier to maintain, like:
    # my ( $name, $date, $something, $somethingelse ) = split/::/;
    # it's a bit easier than trying to remember the order of the fields in $db

    my @events = split/::/;

    print
        Tr(
            td( { -width => '22%' },
                font( { -size => '+1', color => 'gray' },
                    b(
                        "$events[0] $events[1], $events[2]"
                    )
                )
            ),
            td( { -width => '78%' },
                font( { -size => '+1', color => 'black' },
                    $events[3]
                )
            )
        ),
        Tr(
            td( { -colspan => '2'},
                font( { -size => '2' },
                    $events[4]
                )
            )
        );
}

print end_table, end_html;

close FILE or die "Can't close $!\n";