My main editor is now Eclipse 3 and I can recommend it, as long as you have a reasonable cpu.

My previous editor was BBEdit on mac, very basic.
I evaluated ActiveState's Komodo, but went with Eclipse; the only thing I missed was code folding.

The 'testing' release of the e-p-i-c plugin has code folding, which is very nice, but it only does subroutines.

Being able run scripts through my installed perl is great, I usually have a file called test.pl somewhere that I can open up to quickly try something out and run it. I've never really used the debugger integration though.

Auto syntax checking (uses perl -c) is great for productivity; the right scroller will show yellow/red marks for warnings/errors, clicking them will jump to the appropriate line.

Another feature I like is the 'outline' window which lists all the subroutines in the file; clicking one will jump to it in the editor.

The perldoc integration is dodgy, it'll open a DOS window with the documentation, but after hitting q to close, Eclipse will prompt that the documentation wasn't available.

I've just tested the new refactor feature. Select some code, hit refactor and it'll put it out into a new subroutine. Unfortunately the sub was placed at the end of my __DATA__ block.

Running on linux the other day, I had to download Sun's runtime as I couldn't figure out how to get it to work with gnu's.