The biggest problem I've encountered with maintaining large numbers of file handles open is that it tends to cause the filesystem caching to work against you rather than with you.
On NTFS, you can use the native CreateFile() API and provide extra information about the type of use you intend to make of the file. Using FILE_FLAG_NO_BUFFERING, using your own buffering and multi-sector sized writes can prove beneficial in alleviating this.
Most of the limitations are embodied within the (almost POSIX) complient C-runtime semantics. It's quite probable that baypassing these on other filesystems could also be beneficial, but it probably requires fairly detailed knowledge of the FS concerned.
Examine what is said, not who speaks.
"Efficiency is intelligent laziness." -David Dunham
"Think for yourself!" - Abigail
"Memory, processor, disk in that order on the hardware side. Algorithm, algorithm, algorithm on the code side." - tachyon
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