Back to building perl sans -DDEBUGGING ...

Looking at https://github.com/Perl/perl5/issues/16607, it seems to me that another solution would be to build your XS modules from source (ie cpan -i DateTime), rather than installing the port (which was built for a non-debugging perl) provided by the system vendor.
And, that's the option I would take, if my understanding of the issue is correct.
I would not expect any XS module built for a specific configuration of perl to necessarily work on a perl of a different configuration.

Update:
Is there a way to have perl built with DEBUGGING and XS modules not fail?

AFAIK, the XS modules will generally be fine on a -DDEBUGGING perl as long as they are built using that -DDEBUGGING perl.

Cheers,
Rob

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