Technically, yes. But nearly all JSON parsers i've seen are designed to slurp in everything all at once and turn it into a in-memory data structure. So for very large files, you might (or might not) have to cobble together a custom parser that can do a stream-as-you-go approach.
Of course, that's where Perl comes into its own. Munching insanely huge text files is what it was designed for in the first place ;-)
perl -e 'use Crypt::Digest::SHA256 qw[sha256_hex]; print substr(sha256_hex("the Answer To Life, The Universe And Everything"), 6, 2), "\n";'
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