Well, you are looking at such a website, so yes.

There are many modules that can help you with that. One of the oldest and simplest is CGI, but without giving up control you can also use frameworks like CGI::Application or Catalyst that try to seperate HTML code from the data (so that you can independently create the look-and-feel of the website and the contents). These frameworks often use the MVC-Pattern, a well established form of website design

Part of this are modules that fill a html template (the look) with data to create the final web page, for example HTML::Template. Oh and don't forget modules to help with sign-on, cookies, forms,... you name it

By the way, your question suggests that you didn't even use google or the super-search on this website to get some basic information. As a result you have to live with very general answers that might not get you very far.