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:raw:perlio:encoding(UTF-16LE):crlf:utf8

open my $input_fh,
    '<:raw:perlio:encoding(UTF-16LE):crlf:utf8', $input_file
...
open my $output_fh,
    '>:raw:perlio:encoding(UTF-16LE):crlf:utf8', $output_file
    or die "Can't open output file $output_file: $OS_ERROR\n";