"Probably"
... but it depends on the context.
- Where does the webpage come from?
- What is rendering the webpage?
- Where does Perl fit into the system?
You could be talking about having a proxy server, written in Perl, that modifies a page before it gets to the browser.
You could be talking about a bot written in Perl that interacts with a website without a browser being involved.
You could be talking Perl embedded in the server side application.
How you would go about this would depend on what you are actually trying to achieve.
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