I use this setup:

export PERL5LIB=/home/dakkar/localperl:$PERL5LIB
export PERL5_CPANPLUS_CONFIG=/home/dakkar/.cpanplus/config
export PERL_MM_OPT='INSTALLDIRS=perl LIB=/home/dakkar/localperl/ INSTA
+LLBIN=/home/dakkar/bin INSTALLSCRIPT=/home/dakkar/bin/ INSTALLMAN1DIR
+=/home/dakkar/man/man1 INSTALLMAN3DIR=/home/dakkar/man/man3'
function MyBuild {
    perl Build.PL \
        --install_path lib=/home/dakkar/localperl/lib/ \
        --install_path arch=/home/dakkar/localperl/lib/i686-linux-thre
+ad-multi/ \
        --install_path script=/home/dakkar/bin/ \
        --install_path bin=/home/dakkar/bin/ \
        --install_path bindoc=/home/dakkar/man/man1 \
        --install_path libdoc=/home/dakkar/man/man3 \
        "$@"
}
export MANPATH=/home/dakkar/man:$MANPATH
[download]

This way, I have my modules in ~/localperl and scripts and manpages go in usable places. It works both with MakeMaker and Module::Build, provided you use MyBuild instead of perl Build.PL. It also has a localized CPANPLUS config, with the same parameters set per both build systems.

-- 
        dakkar - Mobilis in mobile