I might try that some day. Currently I've got a company Intranet that uses ActiveState 5.6.1 on a Windows environment. I don't have the time to make any drastic changes to that right now. I've got the freedom to do that on my home PC, but I like to keep the environments consistent from home to work because I do a lot of work from home. I'm building a test box, though, and will at least upgrade to a more current Perl version there in the near future.
I've not really had any difficulty with ActiveState until recently.