I'am using C:B under mod_perl (called
Apache-CGI-Builder) for my actual projects and I really like it. It's pretty new thats correct, but the author has first rewritten C:A before he started with C:B, so it seems that he has some experience.
C:B has some great features: overrunning concept (the same handler, i.e. a init handler get executed in every class) and some more which are pretty handy, just read the well organized and easy to read documentation!
As mentioned above i run all my code under mod_perl and the integration is smooth (including some optimzed code for mod_perl (package variables)). The same author has also written a great template engine,
TemplateMagic, it integrates very well with A:C:B, if you have some free time give it a look.
it's true that the perl-code doesn't look like the code you see in other modules, but it's very constant and if you have looked at few .pm's i don't think you have any problems reading it. if you get used to TemplateMagic, or read just the documentation, you see that the author is a real perl guy. TemplateMagic is quite simple but offers the greatest flexibilty i've ever seen in a templateengine!