Anonymous Monk,
The answer is yes, but you probably want something for the general case as well as this specific case.
#!/usr/bin/perl -w
use strict;
my $string = 'John is following jane';
# Specific
$string =~ s/[jJ]ane/##Jane##/;
# To preserve j or J in replacement
# $string =~ s/([jJ]ane)/##$1##/;
# More generic
# $string =~ s/(John is following) (\w+)/$1 \u$2/;
Cheers - L~R
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