I have never used the Perlbrew. Should I use it?

It depends; I would want others to chime in on this. I tried Perlbrew recently; it's a lot closer to downloading and compiling Perl from scratch, so it seems intended for the serious or experienced Perl user that likes to have more control over their Perl than afforded by a turnkey distribution or package manager. So I have the impression of it being overkill for end-users, but that being said, it might still be more beginner friendly than I realize, for example if there's good resources out there for guiding beginners. One advantage it would have is consistency across OSes.

For end-users (i.e. non-programmers) or beginners, I think a more turnkey Perl distribution may be preferable, for example ActivePerl. However, if you're tech-savvy enough to be comfortable with using OS package managers like Homebrew, then that option may work fine: just look into how it organizes pre-packaged Perl modules, and how using tools like cpanm to get any modules that aren't prepackaged will work alongside the prepackaged ones. Maybe ask the package manager's community directly instead for installation advice, since many others in the Perl community won't be experts on it.