Well,
I wrote a complete database-driven website with ODBC.

my $DSN = 'driver={SQL Server};Server=212.233.1.70; database=db;uid=us
+r;pwd=pwusr;'; 
my $dbh = DBI->connect("dbi:ODBC:$DSN") or die "$DBI::errstr\n";
[download]

is the connection string. Only problem I had was that special SQL syntax that was just a bit different then mysql or oracle.

Noticed no speed difference but the database is not yet really heavely taxed...

I would say go for it!!!!
This is the best alternative I found!

--
My opinions may have changed,
but not the fact that I am right