Do you have your App mappings set correctly for IIS? To run perl as a cgi application, type the full path to Perl.exe followed by %s %s. When a script is executed, the first %s will be replaced by the full path to the script, and the second %s will be replaced by the script parameters. To do this go to web site properties/Home Directory tab/Configuration... button/ and edit your paths there. Something like: C:\Perl\bin\perl.exe %s %s