PerlGTK is pretty cool, it's relatively easy to use if you know how to use it. Documentation is completely lacking. I would not try to program with it unless you've programmed with GTK+ in some form or another previously. Most things mimic the C calling sequece pretty well, such as

gtk_label_new("text");
[download]

is

Gtk::Label->new("text");
[download]

and so on.

The bad part is when you get into some of the C calls that return things through the parameter list, i.e. a function that returns a value, but takes 2 pointers in its arguments which it sets to valuable information later. What is the way to mimic this call? Should it return a list of items that it normally would have assigned via pointers, or should it do something else? If it returns a list, then where are the gaps in the arguments, etc.

A lot of figuring it out is hit and miss just trying things out. Alternatively, you can dig through the source code of the example programs that come with perlgtk.

If you're comfortable with perl, perl objects, and modules, and you've programmed with gtk before, go for it. Otherwise, you might want to wait until some documentation is out and about.