P is for Practical | |
PerlMonks |
Re^2: Reduce RAM requiredby onlyIDleft (Scribe) |
on Jan 09, 2019 at 16:10 UTC ( [id://1228259]=note: print w/replies, xml ) | Need Help?? |
I agree with your approach of counting letters and using their frequencies About frequency of A/T/C/G agree again - but but I would much prefer to calculate it across ALL sequences, rather than just 1 sequence at a time - corresponding to one $ID, so that this frequency-compliant sequence randomization is based on global rather than local frequencies. I suspect it will result in even more reduced signal / noise ratio, though I have not tested that yet... Thank you!
In Section
Seekers of Perl Wisdom
|
|