I've played around with Dancer (ie got a Hello World template view up and running) and did a little more in Mojo, but from what I've read so far, the learning curve of Catalyst is far worth it. I agree with the sentiment that it's difficult to learn all three (or more) frameworks enough to make an informed decision, but I dabbled, and it seems like Catalyst is the way to go, especially since my grand plans for this project include potentially thousands of updates per hour, with the potential of hundreds of thousands of records. With that in mind, it seems Catalyst is the clear winner if only based on project size. (Again, this is all based on what I've read/heard.)

Thanks a lot for your input, I appreciate the time and feedback!