You can't go wrong with either so Dip your toes in all three with quickstart, do a quick compare, then dip some more ;)

Similar question at mod_perl website structure with lots of good reading material (aim for the short 1-page links first)

http://iam.richardbucker.com/2011/09/21/mojolicious-first-app/

cpan Mojolicious Dancer Catalyst

mojo generate lite_app MyMojoApp

dancer -a MyDancerApp

catalyst MyCatalystApp

oops, these generators are broken (for me) at the moment , so try it or see http://cgi-app.org/index.cgi?BestPractices

cpan Module::Starter::Plugin::CGIApp Titanium

titanium-starter --module=MyTitaniumApp --author=author --email=email

cgiapp-starter --module=MyCGIAppApp --author=author --email=email

cpan CGI::Application::Generator CGI::Application::Structured