Hi imrags,

I have not benchmarked, but by adding next we can avoid some extra executions. It is not going to boost more performance, but slight improvement will be there.

use strict;
use warnings;

for my $i (1 .. $LastRow)
{    
    if ($Sheet->Range("E$i")->{Value} =~ /MSD/){
                
        next;
        
    }
    else{

            $CB_COUNT++;
        
            if ( $Sheet->Range("J$i")->{Value} !~ /No_/i){
                             
                    $NM_COUNT++;
                        
            }                    
                            
    }
[download]

OP has updated the code. Posted solution for the previous one.
update: Removed extra 'if' statement in 'else' part.