Being a relative newbie to perl (I've been coding different projects in perl for about a year and a half now), I don't make use of POD. I know, bad boy. I prefer to write plain old html (in vi), and put it on a box here all the admins use as a documentation repository. I suppose it all depends on what level of knowledge you currently have, and what you will feel comfortable using.
I know that I fall into this category. When I learn how to use POD (that should be soon too) I'll go back and integrate all of my html docs into the scripts themselves as suggested earlier.
YMMV


Very funny Scotty... Now PLEASE beam down my PANTS!