Technically, yes. But nearly all JSON parsers i've seen are designed to slurp in everything all at once and turn it into a in-memory data structure. So for very large files, you might (or might not) have to cobble together a custom parser that can do a stream-as-you-go approach.
Of course, that's where Perl comes into its own. Munching insanely huge text files is what it was designed for in the first place ;-)