I also use Strawberry Perl Portable Edition, on servers and laptops (enterprise-locked).

Installing CPAN modules works fine with portableshell.bat and you don't need it to execute a Perl script : just use the full path to perl.exe. That's how I call Perl scripts from a batch file.

It's possible to run a Perl script from Notepad++ (stdout only), see https://amazingperl.blogspot.com/2013/01/use-notepad-as-perl-ide.html